Berlin-Brandenburger Forschungsplattform BB3R

Publikationen

Publikationen und Vorträge der Forschungsplattform BB3R


Publikationen:

2018

Lang A, Volkamer A, Behm L, Röblitz S, Ehrig R, Schneider M, Geris L, Wichard J, Buttgereit F (2018) In silico Methods - Computational Alternatives to Animal Testing. ALTEX 2018 Jan. doi:10.14573/altex.1712031

2017

Kaessmeyer S, Sehl J, Khiao In M, Merle R, Richardson K, Plendl J. (2017) Subcellular Interactions during Vascular Morphogenesis in 3D Cocultures between Endothelial Cells and Fibroblasts. Int J Mol Sci. 2017 Dec 1;18(12). pii: E2590. doi: 10.3390/ijms18122590.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B (2017) The target landscape of clinical kinase drugs.Science. 2017; 358(6367). PMID: 29191878

Lemfack MC, Gohlke BO, Toguem SMT, Preissner S, Piechulla B, Preissner R. mVOC 2.0: a database of microbial volatiles. Nucleic Acids Res. 2017 Nov 2. doi: 10.1093/nar/gkx1016. PMID: 29106611

Siramshetty VB, Eckert OA, Gohlke BO, Goede A, Chen Q, Devarakonda P, Preissner S, Preissner R. SuperDRUG2: a one stop resource for approved drugs. Nucleic Acids Res. 2017. doi: 10.1093/nar/gkx1088. PMID: 29140469

Siramshetty V.B., Chen Q. and Preissner R. WITHDRAWN – A One-stop Source for Drug Withdrawals. Pharmazeutische Medizin – Journal of the German Society of Pharmaceutical Medicine, 2017 Oct.

Siramshetty V.B. and Preissner R. Drugs as habitable planets in the space of ‘dark chemical matter’. Drug Discov Today. 2017 Jul 11., doi: 10.1016/j.drudis.2017.07.003, PMID: 28709991.

Blex C, Michaelis S, Schrey AK, Furkert J, Eichhorst J, Bartho K, Quast FG, Marais A, Hakelberg M, Gruber U, Niquet S, Popp O, Kroll F, Sefkow M, Schülein R, Mathias D, Köster H Targeting G-protein-coupled receptors by Capture Compound Mass Spectrometry (CCMS) - a case study with sertindole. Chembiochem. 2017 May 29. doi: 10.1002/cbic.201700152, PMID: 28557180

Hertel M., Hartwig S., Schmidt-Westhausen A.M., Preissner R., Paris S., and Preissner S. Volatile organic compounds in the breath of oral candidiasis patients: a pilot study. Clinical Oral Investigations, 2017 May, DOI:10.1007/s00784-017-2147-6

Schrey A. K., Nickel-Seeber J., Drwal M. N., Zwicker P., Schultze N., Haertel B. and Preissner R. Computational Prediction of Immune Cell Cytotoxicity. Food Chem Toxicol. 2017 May, doi: 10.1016/j.fct.2017.05.041

Manisha Juneja, Dennis Kobelt, Wolfgang Walther, Cynthia Voss, Janice Smith, Edgar Specker, Martin Neuenschwander, Björn-Oliver Gohlke, Mathias Dahlmann, Silke Radetzki, Robert Preissner, Jens Peter von Kries, Peter Michael Schlag, Ulrike Stein;  Statin and Rottlerin small molecule inhibitors restrict colon cancer progression and metastasis via MACC1. PLoS Biol. 2017 May, DOI:10.1371/journal.pbio.2000784

Hartwig S, Raguse JD, Pfitzner D, Preissner R, Paris S, Preissner S. Volatile Organic Compounds in the Breath of Oral Squamous Cell Carcinoma Patients: A Pilot Study. Otolaryngology - Head and Neck Surgery, DOI: 10.1177/0194599817711411,

Pries A. R., Naoum A., Habazettl H., Dunkel M., Preissner R., Coats C. J., Tornada A., Orso F., Van de Werf F. and Wood D. A. CardioScape mapping the cardiovascular funding landscape in Europe. Eur Heart J ehx106. 2017 Apr 25., doi:10.1093/eurheartj/ehx106

Banerjee P, Schrey A. K. and Preissner R. Computational Methods for the Prediction of Chemical Toxicity. Pharmazeutische Medizin – Journal of the German Society of Pharmaceutical Medicine, 2017 Mar 21, ISSN 2191-6039

Gillissen B, Richter A, Richter A, Preissner R, Schulze-Osthoff K, Essmann F and Daniel PT
Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma. J Biol Chem. 2017 Apr 21;292(16):6478-6492., PMID: 28154184

Giulbudagian M, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M. Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels. Theranostics 2018; 8(2):450-463. doi:10.7150/thno.21668. Available from http://www.thno.org/v08p0450.htm

Bock, S.; Said, A.; Müller, G.; Schäfer-Korting, M.; Zoschke, C.; Weindl, G. Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization. Toxicol In Vitro (2017) 46:77-85 doi: 10.1016/j.tiv.2017.09.019 [Epub ahead of print]

Corte, G.M.; Plendl, J; Hünigen, H; Richardson, K.C.; Gemeinhardt, O.; Niehues, S.M Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography - A morphometric study of the mandibular canal. PLoS ONE (2017) 12(9):e0184889 doi: 10.1371/journal.pone.0184889

Zscheppang, K.; Berg, J.; Hedtrich, S.; Verheyen, L.; Wagner, D.E.; Suttorp, N.; Hippenstiel, S.; Hocke, A.C. Human pulmonary 3D models for translational research. Biotechnol J (2017) doi: 10.1002/biot.201700341 [Epub ahead of print] 

Hohlbaum, K.; Bert, B.; Dietze, S.; Palme, R.; Fink, H.; Thöne-Reineke, C. Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice - Assessing the degree of distress. PLoS ONE (2017) 12(6): e0179588 doi: 10.1371/journal.pone.0179588


2016

Kaessmeyer, S.; Sehl, J.; Khiao-In, M.; Hiebl, B.; Merle R.; Jung, F.; Franke RP.; Plendl, J. Organotypic soft-tissue co-cultures: Morphological changes in microvascular endothelial tubes after incubation with radiographic contrast media. Clin Hemorheol Microcirc. 2016 DOI: 10.3233/CH-168119

Zhang, N.; Said, A.; Wischke, C.; Kral, V.; Brodwolf, R.; Volz, P.; Boreham, A.; Gerecke, C.; Li, W.; Neffe, A. T.; Kleuser, B.; Alexiev, U.; Lendlein, A.; Schäfer-Korting, M. Poly[acrylonitrile-co-(N-vinyl pyrrolidone)]nanoparticles - composition-dependent skin penetration enhancement of a dye probe and biocompatibility Eur J Pharm Biopharm 2016 http://dx.doi.org/10.1016/j.ejpb.2016.10.019

Banerjee, P.; Siramshetty, V. B.; Drwal, M. N.; Preissner, R. Computational methods for prediction of in vitro effects of new chemical structures. J Cheminform, 8:51. (2016) doi: 10.1186/s13321-016-0162-2

Preissner, S.; Kastner, I.; Schütte, E.; Hartwig, S.; Schmidt-Westhausen, A. M.; Paris, S.; Preissner, R.; Hertel, M. Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study. Mycoses, 59(7):467-75. (2016) doi: 10.1111/myc.12495

Riehle, M.; Büscher, A. K.; Gohlke, B. O.; Kaßmann, M.; Kolatsi-Joannou, M.; Bräsen, J. H.; Nagel, M.; Becker, J. U.; Winyard, P.; Hoyer, P. F.; Preissner, R.; Krautwurst, D.; Gollasch, M.; Weber, S.; Harteneck, C. TRPC6 G757D Loss-of-Function Mutation Associates with FSGS J Am Soc Nephrol, 27(9):2771-83. (2016)  doi: 10.1681/ASN.2015030318

Klaeger, S.; Gohlke, B.; Perrin, J.; Gupta, V.; Heinzlmeir, S.; Helm, D.; Qiao, H.; Bergamini, G.; Handa, H.; Savitski, M. M.; Bantscheff, M.; Medard, G.; Preissner, R.; Kuster, B. Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors ACS Chem Biol, 20;11(5):1245-54. (2016) doi:10.1021/acschembio.5b01063

Bäcker, C.; Drwal, M. N.; Preissner, R.; Lindequist, U. Inhibition of DNA-Topoisomerase I by Acylated Triterpene Saponins from Pittosporum angustifolium Lodd. Nat Prod Bioprospect, 6(2):141-7. (2016) doi: 10.1007/s13659-016-0087-5

Hertel, M.; Hartwig, S.; Schütte, E.; Gillissen, B.; Preissner, R.; Schmidt-Westhausen, A. M.; Paris, S.; Kastner, I.; Preissner, S. Identification of signature volatiles to discriminate Candida albicans, glabrata, krusei and tropicalis using gas chromatography and mass spectrometry. Mycoses, 59(2):117-26. (2016) doi: 10.1111/myc.12442

Hertel, M.; Preissner, R.; Gillissen, B.; Schmidt-Westhausen, A. M.; Paris, S.; Preissner, S. Detection of signature volatiles for cariogenic microorganisms. Eur J Clin Microbiol Infect Dis, 35(2):235-44. (2016) doi: 10.1007/s10096-015-2536-1

Weidner, C.; Steinfath, M.; Opitz, E.; Oelgeschläger, M.; Schönfelder, G. Defining the optimal animal model for translational research using gene set enrichment analysis, EMBO Molecular Medicine, 2016e201506025. doi: 10.15252/emmm.201506025

Zoschke, C.; Ulrich, M.; Sochorova, M.; Wolff, C.; Vavrova, K.; Ma, N.; Ulrich, C.; Brandner, J. M.; Schäfer-Korting, M. The barrier function of organotypic non-melanoma skin cancer models. J Control Release, 233 (2016) 10-18. doi: 10.1016/j.jconrel.2016.04.037.

Siramshetty, V. B.; Nickel, J.; Omieczynski, C.; Gohlke, B. O.; Drwal, M. N.; Preissner, R. WITHDRAWN - a resource for withdrawn and discontinued drugs. Nucleic Acids Res. 44, D1080-D1086 (2016) doi: http://dx.doi.org/10.1093/nar/gkv1192

Gohlke, B.-O.; Nickel J.; Otto R.; Dunkel M.; Preissner R. CancerResource—updated database of cancer-relevant proteins, mutations and interacting drugs. Nucleic Acids Research 44:D932-D937 (2016) doi:10.1093/nar/gkv1283


2015

Khiao-In, M.; Wallmeyer, L.; Hedtrich, S.; Richardson, K.C.; Plendl, J.; Kaessmeyer, S. The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs – A morphological study. Clin Hemorheol Microcirc. 61 (2015) 157-174 doi: 10.3233/CH-151988.

Zoschke, C.; Schilrreff, P.; Romero, E. L.; Brandner, J. M.; Schäfer-Korting, M. Dendritic Nanoparticles for Cutaneous Drug Delivery - Testing in Human Skin and Reconstructed Human Skin. Curr Pharm Des, 21 (2015) 2784-2800. doi: 10.2174/1381612821666150428142515

Drwal, M. N.; Siramshetty, V.B.; Banerjee, P.; Goede, A.; Preissner, R.; Dunkel, M.Molecular similarity-based predictions of the Tox21 screening outcome. Front. Environ. Sci. 3:54 (2015) http://dx.doi.org/10.3389/fenvs.2015.00054

 

2014

Nickel, J.; Gohlke, B.-O.; Erehman, J.; Banerjee, P.; Rong, W. W.; Goede, A.; Dunkel, M.; Preissner,  R. SuperPred: update on drug classification and target prediction. Nucleic Acids Research 42:W26-W31 (2014) doi:10.1093/nar/gku477

Weber, M.; Zoschke, C.; Sedighi, A.; Fleige, E.; Haag, R.; Schäfer-Korting, M. Free energy simulations of cargo-carrier interactions for Core-Multishell nanotransporters. J Nanosci Nanotechnol 5:234. (2014) doi:10.4172/2157-7439.1000234

 

2013

Durmaz, V.: Schmidt, S.; Sabri, P.; Piechotta, C.; Weber, M. Hands-off linear interaction energy approach to binding mode and affinity estimation of estrogens. J Chem Inf Model 53:2681-2688 (2013) doi:10.1021/ci400392p

 


Vorträge:

2017

10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, USA, August 20-24, 2017 Annemarie Lang (AG Buttgereit): “Simulating Osteoarthritis In Vitro with Human Scaffold-Free 3D Cartilage Transplants”

Moritz Pfeiffenberger (AG Buttgereit): “Modelling the Initial Phase of Fracture Healing In Vitro”

Alexandra Damerau (AG Buttgereit): “Development of an In Vitro Multi-Component 3D Arthritic Joint Model”

Katharina Hohlbaum (AG Thöne-Reineke): "Severity Classification of Repeated Isoflurane Anesthesia in C57BL/6J Mice:
Assessing Well-Being and Distress"

Computer Aided Drug Design (GRS), USA; July 2017
Dr. Priyanka Banerjee (AG Preissner) "Computational Methods for the Prediction of Chemical Toxicity"

Drug Discovery and Therapy World Congress 2017, Boston, USA, July 10-13, 2017
Monika Schäfer-Korting: “Rethinking drug development – improving translational research”

Monika Schäfer-Korting: The barrier function of organotypic nonmelanomaskin cancer models“

University of Bonn (Life Science Informatics) Computational Methods for the Prediction of Chemical Toxicity, June 2017,
Dr. Priyanka Banerjee (AG Preissner) Invited Lecture series

Mini-Symposium Biomimetic tissues, Sao Paulo, Brasilien
Schäfer-Korting, M: Monika Schäfer-Korting:new drugs”,


2016

35. Jahrestagung Deutsche Gesellschaft für Klinische Mikrozirkulation und Hämorheologie, Mainz, Germany (4.- 5. November 2016)

Kaessmeyer, S.; Sehl, J.; Khiao In, M.; Hiebl, B.; Jung, F.; Frank, R. P.; Plendl, J. Effekt von Röntgenkontrastmitteln auf die in vitro Angiogenese mikrovaskulärer Endothelzellen in 3-dimensionalen organtypischen Kokulturen.

9th Doctoral Symposium and DRS-presentation seminar, Berlin, Germany (16. September 2016)

Khiao In, M.; Hedtrich, S.; Kaessmeyer, S.; Plendl, J. In vitro and in situ studies in human and porcine skin and skin constructs.

45. Seminar über Versuchstiere und Tierversuche, Berlin, Germany (13.-14. September 2016)

Nitezki T. Charakterisierung von Stereotypien bei Mäusen.

14th Meeting of the European Epidermal Barrier Research Network, Munich, Germany (7.-8. September 2016)

Wolff, C. Reconstructed human skin from aged fibroblasts emulates aspects of physiological skin aging

17th Annual Congress of EUSAAT & 20th European Congress on Alternatives to Animal Testing, Linz, Austria (24.-27. August 2016)

Schäfer-Korting, M.; Hedtrich, S.; Kleuser, B.; Japtok, L.; Lauster, R.; Luch, A.; Pries, A.; Preissner, R.; Said, A.; Plendl, J.; Schönfelder, G.; Thöne-Reineke, C.; Weber, M.; Weindl, G. BB3R – Educating the next generation of scientists.

Hedtrich, S. Inflammatory skin disease models.

Hohlbaum, K.; Bert, B.; Dietze, S.; Fink, H.; Thöne-Reineke, C. Repeated isoflurane anesthesia in female mice – assessing the severity of stress.

Müller, G.; Bock, S.; Zoschke, C.; Said, A.; Schäfer-Korting, M.; Weindl, G. Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization.

Hausmann, C.; Wolff, C.; Darvin, M.; Tigges, J.; Lademann, J.; Fritsche, E.; Zoschke, C.; Schäfer-Korting, M. Chronologically-aged fibroblasts significantly alter the morphology of reconstructed human skin.

Schwengel, K.; Namsolleck, P.; Lucht, K.; Clausen, B.H.; Lambertsen, K.L.; Esquitino, V.V.; Thöne-Reineke, C.; Müller, S.; Widdop, R.E.; Denton, K.M.; Horiuchi, M.; Iwai, M.; Boato, F.; Dahlöf, B.; Hallberg, A.; Unger T.; Steckelings, U.M. Refinement and reduction strategies in experimental stroke.

Thöne-Reineke, C. Advanced training course for Veterinarians to qualify for Animal Welfare Officer.

 

82. Jahrestagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, Berlin, Germany (29. February-03. March 2016)

Schäfer-Korting, M. Alternative Methoden in der Toxikologie (Plenarvortrag)


2015

34. Jahrestagung Deutsche Gesellschaft für Klinische Mikrozirkulation und Hämorheologie, Regensburg, Germany (27.-28. November 2015)

Khiao-In, M.; Hedtrich, S.; Wallmeyer, L.; Plendl, J.; Kaessmeyer, S. The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs - A morphological study. (2. Preis für besten Vortrag)

IV Escuela de Nanomedicina, Buenos Aires, Argentinien (25.-28. November 2015)

Schäfer-Korting, M. In-vitro and ex-vivo approaches in pharmaclogy - a translational perspective.

World Conference on Regenerative Medicine, Leipzig, Germany (21.-23. October 2015)

Hübner, J. Combining Organ Equivalents Using the Multi-Organ-Chip Technology

16th Annual Congress of EUSAAT & 19th European Congress on Alternatives to Animal Testing, Linz, Austria (20.-23. September 2015)

Schäfer-Korting, M.; Weindl, G.; Kral, V.; Plendl, J.; Thöne-Reineke, C.; Lauster, R.; Pries, A. R.; Preissner, R.; Weber, M.; Kleuser, B.; Luch, A.; Schönfelder, G. The Berlin-Brandenburg Research Platform BB3R and integrated graduate school.

Hübner, J.; Maschmeyer, I.; Lorenz, A. K.; Ramme, A.; Hasenberg, T.; Schimek, K.; Drewell, C.; Bauer, S.; Lauster, R.; Marx, U. A microfluidic Four-Organ-Chip –a potential tool for ADME profiling

10th International Congress of Pharmaceutical Sciences, Ribeirao Preto, Brasilien (05. September 2015)

Schäfer-Korting, M. Challenges and perspectives in research on alternatives to animal testing.

8th Meeting of the Young Generation of Veterinary Anatomists, Poznań, Poland (15.-17. July 2015)

Corte, G.M.; Plendl, J.; Hünigen, H.; Niehues, S.M. 3D-CT morphometric studies of the mandibula in Göttingen Minipigs®.

4th International Conference "Strategies in Tissue Engineering", Würzburg, Germany (10.-12. June 2015)

Hübner, J.; Wagner, I.; Materne, E.-M.; Lorenz, A.; Schimek, K.; Ramme, A.; Horland, R.; Sonntag, F.; Lauster, R.; Marx, U. The Multi-Organ-Chip platform –a new tool for predictive substance testing.

 

2014

Auftaktveranstaltung des öffentlichen Forums „Tierschutz in der medizinischen Forschung“, Berlin, Germany (24. September 2014)

Plendl, J. In-vitro-Modelle der Bildung von Blutgefäßen

 


 

Poster:

 

2016

11th International Particle Toxicology Conference, Singapore (26.-30. September 2016)

Leibrock, L.; Wagener, S.; Jungnickel, H.; Tentschert, J.; Laux, P.; Luch, A. Dosimetry establishment for in vitro inhalation toxicity studies at the air-liquid interface.

17th Annual Congress of EUSAAT & 20th European Congress on Alternatives to Animal Testing, Linz, Austria (24.-27. August 2016)

Nitezki, T.; Schumacher, F.; Bornhorst, J.; Kleuser, B.; Krämer, S. Stereotypic mice: To use or not to use, that is the question.

Zhang, N.; Said, N.; Wischke, C.; Kral, V.; Brodwolf, R.; Volz, P.; Boreham, A.; Gerecke, C.; Li, W.; Neffe, A.; Kleuser, B.; Alexiev, U.; Lendlein, A.; Schäfer-Korting, M. Combining human cell-based assays to identify biocompatible poly[acrylonitrileco-(N-vinyl pyrrolidone)] nanoparticles

Joint Conference EAVA & WAHVM 2016, Vienna, Austria (27.-30. July 2016)

Corte, G.M.; Plendl, J.; Niehues, S. M.; Hünigen, H. Assessing mandibular morphometric changes in the growing Göttingen Minipig™ using 3D computed tomography.

Frontiers in CardioVascular Biology, Florence, Italy (08.-10. July 2016)

Rong, W. W.; Reglin, B.; Xiang, W.; Nitzsche, B.; Maibier, M.; Pries, A. R. “Emerging angiogenesis” in the chick chorioallantoic membrane. An in vivo study. (Travel Award)

Skin Forum Annual Meeting, London, UK (21.-22. June 2016)

Löwa, A.; Charbaji, N.; Hedtrich, S. Generation of in vitro skin models using hair follicle-derived cells.

3D Cell Culture 2016: How close to 'in vivo' can we get? Models, applications & translation, Freiburg, Germany (19.-21. April 2016)

Hübner, J.; Jahns, F.; Maschmeyer, I.; Lorenz, A.; Gerlach, S.; Kühnl, J.; Giese, C.; Lauster, R.; Marx, U. Integrating Immunological Aspects into a Multi-Organ-Chip Platform

Tagung der DVG-Fachgruppe "Physiologie und Biochemie", Berlin, Germany (30. March-03. April 2016)

Khiao In, M.; Hedtrich, S.; Wallmeyer, L.; Plendl, J.; Kaessmeyer, S. Identification of lysosomes in 3D skin constructs that may be progenies of lamellar bodies in stratified soft-cornified epidermis.

 

82. Jahrestagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, Berlin, Germany (29. February-03. March 2016)

Abstracts available: Naunyn-Schmiedeberg's Archives of Pharmacology, 389 (2016) 1-104.

Wolff, C.; Ulrich, M.; Brandner; J. M.; Ulrich, C.; Zoschke, C.; Schäfer-Korting, M. Development and Characterization of Cutaneous Squamous Cell Carcinoma.

Hedtrich, S.; Japtok, L.; Kleuser, B.; Kral, V.; Lauster, R.; Luch, A.; Plendl, J.; Preissner, R.; Schäfer-Korting, M.; Schönfelder, G.; Thöne-Reineke, C.; Weber, M.; Weindl, G. The Berlin-Brandenburg Research Platform BB3R and Integrated Graduate Program.

Bock, S.; Zoschke, C.; Said, A.; Schäfer-Korting, M.; Müller, G.; Weindl, G. Functional characterization of reconstructed human skin with integrated Langerhans-like cells.

Siramshetty, V. B.; Banerjee, P.; Dunkel, M.; Goede, A.; Preissner, R.; Drwal, M. N. Computational methods for prediction of in vitro activity of new chemical structures.

Nickel-Seeber, J.; Schrey, A. K.; Drwal, M. N.; Preissner, R. In silico prediction of immunotoxicity.

Rakers, C.; Schumacher, F.; Meinl, W.; Glatt, H.; Kleuser, B.; Wolber, G. Computer-based prediction of sulfotransferase 1E1 metabolism using 3D pharmacophores from molecular dynamics simulations.

Khiao In, M.; Wallmeyer, L.; Hedtrich, S.; Plendl, J.; Kaessmeyer, S. Full-thickness skin constructs: endothelialized versus non-endothelialized. A morphological comparison regarding epidermal differentiation.

Hübner, J.; Maschmeyer, I.; Lorenz, A.; Gerlach, S.; Kühnl, J.; Giese, C.; Lauster, R.; Marx, U. First steps of integrating immunology aspects into a multi-organ-chip platform.

Löwa, A.; Charbaji, N.; Hedtrich, S. Generation of in vitro skin models using ORS cells.

Hohlbaum, K.; Bert, B.; Dietze, S.; Fink, H.; Thöne-Reineke, C. Repeated anesthesia in rodents – Assessing severity levels.

Rudeck, J.; Vogl, S.; Banneke, S.; Bert, B.; Kurreck, J.; Schönfelder, G. Individualized pain suppression in mice.

Corte, G. M.; Plendl, J.; Niehues, S. M.; Hünigen, H. Morphometry of the mandibula in Göttingen Minipigs™: Refining orofacial surgical experiments by 3D-computed tomography.

Nitezki, T.; Kleuser, B.; Krämer, S. Characterization of stereotypies in FVB/N-Mice and its impact on immune system and metabolism.

Rong, W. W.; Reglin, B.; Xiang, W.; Nitzsche, B.; Maibier, M.; Pries, A. R. “Emerging angiogenesis” in the chick chorioallantoic membrane.

Durmaz, V.; Weber, M. Risk assessment on sulfamethoxazole and carbamazepine transformation products using molecular dynamics simulations.


2015

BSRT Symposium: Revealing Prometheus' Secrets: Current Technologies for Tissue and Organ Regeneration and their Clinical Perspective, Berlin, Germany (02.-04. December 2015)

Hübner, J.; Maschmeyer, I.; Lorenz, A. K.; Ramme, A.; Hasenberg, T.; Schimek, K.; Drewell, C.; Bauer, S.; Lauster, R.; Marx, U. Microfluidic four-organ-chip - a potential tool for adme profiling

37th Annual Meeting of the German Society for Microcirculation and Vascular Biology, Hannover, Germany (24.- 26. September 2015)

Rong, W. W.; Reglin, B.; Xiang, W.; Nitzsche, B.; Maibier, M.; Pries, A. R. “Emerging angiogenesis” in the chick chorioallantoic membrane. An in vivo study.

16th Annual Congress of EUSAAT & 19th European Congress on Alternatives to Animal Testing, Linz, Austria (20.-23. September 2015) 

Abstracts available: ALTEX Proceedings 4:261.

Wolff, C.; Zoschke, C.; Kral, V.; Brandner, J.; Schäfer-Korting, M. Impaired skin barrier function of cutaneous squamous cell carcinoma.

Schäfer-Korting, M.; Zoschke, C.; Hönzke, S.; Alexiev, U.; Boreham, A.; Löwenau, L.; Hausmann, C.; Wallmeyer, L.; Tigges, J.; Krutmann, J.; Hedtrich, S.; Fritsche, E. Reconstructed human skin pioneers the implementation of diversity into preclinical testing in vitro.

Bock, S.; Zoschke, C.; Müller, G.; Schäfer-Korting, M.; Said, A.; Weindl, G. Functional characterization of reconstructed skin containing in vitro generated Langerhans cells.

Corte, G. M.; Plendl, J; Hünigen, H; Niehues, S. M. Refinement of orofacial surgical experiments in the Göttingen Minipig™: Morphometry of the mandibula by 3D-computed tomography.

Wallmeyer, L.; Wolff, C.; Hedtrich, S. Influence of CD4+ T cell migration into a filaggrin deficient skin model in terms of skin barrier proteins and barrier function.

Banerjee, P.; Siramshetty, V.; Drwal, M.; Dunkel, M.; Preissner, R. Systematic assessment of different computational approaches for prediction of toxic effects of new chemical structures.

Löwa, A.; Charbaji, N.; Wolff, C.; Hedtrich, S. Generation of in vitro skin models using ORS cells.

Lange Nacht der Wissenschaften, Berlin, Germany (13. June 2015)

Khiao In, M.; Corte, G. M. 3-R-Konzept: Refine, Reduce, Replace im Institut für Veterinär-Anatomie.

24th ESACT Meeting, Barcelone, Spain (31. May - 03. June 2015)

Hübner, J.; Wagner, I.; Lorenz, A.; Rings, T.; Gerlach, S.; Schepky, A.; Kühnl, J.; Horland, R.; Lauster, R.; Marx, U. Perfused 2-organ-chip sensitization assay combining primary dendritic cells and human epidermis

82. Jahrestagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, Berlin, Germany (29. February - 01. March 2015)

Corte, G.M.; Plendl, J.; Niehues, S. M.; Hünigen, H. Morphometry of the mandibula in Göttingen Minipigs™: Refining orofacial surgical experiments by 3D-computed tomography.


2014

9th World Congress on Alternatives and Animal Use in the Life Sciences, Prague, Czech Republic (24.-28. August 2014).

Abstracts available: Altex Proceedings, 231.

Hübner, J.; Wagner, I.; Lorenz, A.; Lade, T.: Gerlach, S.; Schepky, A.; Kühnl, J.; Horland, R.; Lauster, R.; Marx, U. A Multi-Organ-Chip-based dynamic sensitization assay comprising human epidermis and primary dendritic cell co-culture

Zoschke, C.; Merk, H. F.; Küchler, S.; Weindl, G.; Schäfer-Korting, M. Evaluating reconstructed cutaneous squamous cell carcinoma. (Travel Award)

The 18th Annual Meeting of Society for Dermopharmacy, Berlin, Germany (07.-09. April 2014)

Zoschke, C., Löwenau L.; Wattanapitayakul, S.; Merk, H. F.; Weindl, G.; Schäfer-Korting, M. Organotypic Models mimic Premature Ageing and Cutaneous Squamous Cell Carcinoma. (Poster Award)

BMBF-de